RSPO1 Mouse Monoclonal Antibody [Clone ID: 7A6]
CAT#: AM06311SU-N
RSPO1 mouse monoclonal antibody, clone 7A6, Ascites
Need it in bulk or conjugated?
Get a free quote
CNY 5,346.00
货期*
5周
规格
Specifications
Product Data | |
Clone Name | 7A6 |
Applications | WB |
Recommend Dilution | ELISA: 1/10000. Western Blot: 1/500 - 1/2000. |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Purified recombinant fragment of R-spondin1 expressed in E. Coli. |
Specificity | Recognizes R-Spondin-1 |
Formulation | State: Ascites State: Ascitic fluid containing 0.03% Aodium Azide. |
Conjugation | Unconjugated |
Storage Condition | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. |
Gene Name | R-spondin 1 |
Database Link | |
Background | R-spondin1, also known as RSPO1, CRISTIN3, FLJ40906 is a member of the R-spondin family and a 28.9kDa secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.It is activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. |
Synonyms | R-spondin-1 |
Reference Data |
Documents
Product Manuals |
FAQs |
SDS |
Resources
抗体相关资料 |
Customer
Reviews
Loading...