VEGF Receptor 2 (KDR) Mouse Monoclonal Antibody [Clone ID: 4B4]

Specifications

Product Data
Clone Name	4B4
Applications	ELISA, FC, IF, WB
Recommend Dilution	Western blot: 1/500-1/2000. Immunofluorescence: 1/200-1/1000. Flow Cytometry: 1/200-1/400. ELISA: 1/10000.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant extracellular fragment of human VEGFR-2 / KDR (aa20-764) fused with hIgGFc tag expressed in HEK293 cells.
Specificity	This antibody recognizes Human VEGFR-2 / KDR. Other species not tested.
Formulation	State: Ascites State: Ascitic fluid containing 0.03% Sodium Azide
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	152 kDa
Gene Name	kinase insert domain receptor
Database Link	Entrez Gene 3791 Human UniProt ID P35968
Background	KDR has also been designated as VEGFR-2 (Vascular endothelial growth factor receptor 2), CD309 (cluster of differentiation 309) and Flk-1 (fetal liver kinase 1). Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. KDR is one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas.
Synonyms	VEGFR2, FLK1, KDR, VEGF Receptor 2
Reference Data

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