ATP2C1 Mouse Monoclonal Antibody [Clone ID: 4G12]

Specifications

Product Data
Clone Name	4G12
Applications	ELISA, IHC, WB
Recommend Dilution	Western Blot: 1/500 - 1/2000. Immunohistochemistry on paraffin sections: 1/200 - 1/1000. ELISA: 1/10000.
Reactivity	Human, Monkey
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of ATP2C1 expressed in E. Coli.
Specificity	This antibody reacts to ATP2C1.
Formulation	State: Ascites State: Ascitic fluid containing 0.03% sodium azide.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	100 kDa
Gene Name	ATPase secretory pathway Ca2+ transporting 1
Database Link	Entrez Gene 27032 Human UniProt ID P98194
Background	ATP2C1, also known as PMR1, it belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium. The human homologue, ATP2C1 (alsodesignated SPLA in rat), also regulates the transport of calcium in the Golgicomplex and is related to other P-type ATPases family members, such as thesarco(endo)plasmic calcium ATPase (SERCA) and the plasma membrane calciumATPase (PCMA). ATP2C1 is a transmembrane protein that exists as twosplice variants, which vary by 20 amino acids. Defects in ATP2C1 cause Hailey-Hailey disease, which is an autosomal dominant disorder that is characterized by blisters and erosions of the skin. These findings provide further evidence that PMR1 plays a key role in maintaining the integrity of the epidermis by controlling intracellular calcium signaling.
Synonyms	ATPase 2C1, KIAA1347, PMR1L, HUSSY-28, ATP-dependent Calcium pump PMR1
Reference Data

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