Integrin alpha 5 (ITGA5) Mouse Monoclonal Antibody [Clone ID: 10F6]

CAT#: AM06388SU-N

Integrin alpha 5 (ITGA5) mouse monoclonal antibody, clone 10F6, Ascites



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CNY 5,346.00


货期*
5周

规格
    • 100 ul

Product images

Specifications

Product Data
Clone Name 10F6
Applications ELISA, FC, IHC, WB
Recommend Dilution Western Blot: 1/500 - 1/2000.
Immunohistochemistry on paraffin sections: 1/200 - 1/1000.
Flow cytometry: 1/200 - 1/400.
ELISA: 1/10000.
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen Purified recombinant fragment of human ITGA5 expressed in E. Coli.
Specificity This antibody reacts to ITGA5.
Formulation State: Ascites
State: Ascitic fluid containing 0.03% sodium azide.
Conjugation Unconjugated
Storage Condition

Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.

Predicted Protein Size 114 kDa
Gene Name integrin subunit alpha 5
Background The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. Integrin alpha 5 is a heterodimer that associates noncovalently with CD29/integrin beta 1 subunit to form the alpha-5-beta-1 very late antigen (VLA-5) complex. VLA-5 is a fibronectin receptor that is expressed on thymocytes, T-cells, monocytes and platelets. It is also found on very early B-cells and activated B-cells. VLA-5-mediated binding to fibronectin sends a costimulatory signal to T-cells and enhances Fc-gamma-R- and complement receptor-mediated phago-cytosis. It is also involved in monocyte migration into extracellular tissues.
Synonyms Integrin alpha-5, Fibronectin receptor subunit alpha, Integrin alpha-F, VLA-5, VLA5, FNRA
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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