USP7 Mouse Monoclonal Antibody [Clone ID: 5F11]

CAT#: AM06486SU-N

USP7 mouse monoclonal antibody, clone 5F11, Ascites



Need it in bulk or conjugated?
Get a free quote

CNY 5,346.00


货期*
5周

规格
    • 100 ul

Product images

Specifications

Product Data
Clone Name 5F11
Applications ELISA, WB
Recommend Dilution ELISA: 1/10000.
Western Blot: 1/500 - 1/2000.
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen Purified recombinant fragment of Human HAUSP expressed in E. Coli.
Specificity Recognizes HAUSP
Formulation State: Ascites
State: Ascitic fluid containing 0.03% Sodium Azide.
Conjugation Unconjugated
Storage Condition Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Predicted Protein Size 128 kDa
Gene Name ubiquitin specific peptidase 7 (herpes virus-associated)
Background USP7 or HAUSP is a ubiquitin specific protease or a deubiquitylating enzyme that cleaves ubiquitin from its substrates. Since ubiquitylation (polyubiquitination) is most commonly associated with the stability and degradation of cellular proteins, HAUSP acitivity generally stabilizes its substrate proteins. HAUSP is most popularly known as a direct antagonist of Mdm2, the E3 ubiquitin ligase for the tumor suppressor protein, p53.Normally, p53 levels are kept low in part due to Mdm2-mediated ubiquitylation and degradation of p53. Interestingly, in response to oncogenic insults, HAUSP can deubiquitinate p53 and protect p53 from Mdm2-mediated degradation, indicating that it may possess a tumor suppressor function for the immediate stabilization of p53 in response to stress. Another important role of HAUSP function involves the oncogenic stabilization of p53. Oncogenes such as Myc and E1A are thought to activate p53 through a p19 alternative reading frame (p19ARF, also called ARF)-dependent pathway, although some evidence suggests ARF is not essential in this process. An intriguing possibility is that HAUSP provides an alternative pathway for safeguarding the cell against oncogenic insults.
Synonyms Ubiquitin carboxyl-terminal hydrolase 7
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
Customer Reviews 
Loading...