B7H3 (CD276) Mouse Monoclonal Antibody [Clone ID: 6A1]

Specifications

Product Data
Clone Name	6A1
Applications	ELISA, FC, IHC, WB
Recommend Dilution	ELISA: 1/10000. Western Blot: 1/500 - 1/2000. Flow Cytometry: 1/200 - 1/400. Immunohistochemistry on Paraffin Sections: 1/200 - 1/1000.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of Human CD276 expressed in E. Coli.
Specificity	Recognizes CD276
Formulation	State: Ascites State: Ascitic fluid containing 0.03% Sodium Azide.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	57 kDa
Gene Name	CD276 molecule
Database Link	Entrez Gene 80381 Human UniProt ID Q5ZPR3
Background	CD276 is a type I transmembrane protein that induces the proliferation of CD4+ and CD8+ T cells, enhances the generation of cytotoxic T cells and selectively stimulates the production of interferon gamma. Expression of CD276 can be induced on dendritic cells and monocytes by inflammatory cytokines, and is also widely expressed in peripheral tissues including the heart, kidney, testis and colon. In humans, CD276 exists as two isoforms which result from gene duplication and differential splicing.CD276 is reported to have therapeutic potential for the regulation of cell-mediated immune responses to cancer, particularly in conjunction with anti-angiogenic therapy.
Synonyms	B7 homolog 3, 4Ig-B7-H3, PSEC0249
Reference Data

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