E Cadherin (CDH1) Mouse Monoclonal Antibody [Clone ID: 7H12]
CAT#: AM06535SU-N
E Cadherin (CDH1) mouse monoclonal antibody, clone 7H12, Ascites
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CNY 5,346.00
货期*
5周
规格
Specifications
Product Data | |
Clone Name | 7H12 |
Applications | ELISA, FC, IHC, WB |
Recommend Dilution | ELISA: 1/10000. Western Blot: 1/500 - 1/2000. Flow Cytometry: 1/200 - 1/400. Immunohistochemistry on Paraffin Sections: 1/200 - 1/1000. |
Reactivity | Human, Monkey, Mouse |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Purified recombinant fragment of Human CDH1 expressed in E. Coli. |
Specificity | Recognizes CDH1 (CD324 / Cadherin-1). |
Formulation | State: Ascites State: Ascitic fluid containing 0.03% Sodium Azide. |
Conjugation | Unconjugated |
Storage Condition | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Predicted Protein Size | 135 kDa |
Gene Name | cadherin 1 |
Database Link | |
Background | E-Cadherin is a 120 kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression.Tissue specificity: Non-neural epithelial tissues. |
Synonyms | Epithelial cadherin, E-cadherin, Uvomorulin, CAM 120/80, CDH1, CDHE, UVO |
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