E Cadherin (CDH1) Mouse Monoclonal Antibody [Clone ID: 7H12]

CAT#: AM06535SU-N

E Cadherin (CDH1) mouse monoclonal antibody, clone 7H12, Ascites



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CNY 5,346.00


货期*
5周

规格
    • 100 ul

Product images

Specifications

Product Data
Clone Name 7H12
Applications ELISA, FC, IHC, WB
Recommend Dilution ELISA: 1/10000.
Western Blot: 1/500 - 1/2000.
Flow Cytometry: 1/200 - 1/400.
Immunohistochemistry on Paraffin Sections: 1/200 - 1/1000.
Reactivity Human, Monkey, Mouse
Host Mouse
Clonality Monoclonal
Immunogen Purified recombinant fragment of Human CDH1 expressed in E. Coli.
Specificity Recognizes CDH1 (CD324 / Cadherin-1).
Formulation State: Ascites
State: Ascitic fluid containing 0.03% Sodium Azide.
Conjugation Unconjugated
Storage Condition Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Predicted Protein Size 135 kDa
Gene Name cadherin 1
Background E-Cadherin is a 120 kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression.Tissue specificity: Non-neural epithelial tissues.
Synonyms Epithelial cadherin, E-cadherin, Uvomorulin, CAM 120/80, CDH1, CDHE, UVO
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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