CYP1A1 Mouse Monoclonal Antibody [Clone ID: 6G5]

Specifications

Product Data
Clone Name	6G5
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA: 1/10000. Western Blot: 1/500-1/2000. Immunohistochemistry on Paraffin Sections: 1/200-1/1000.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of Human CYP1A1 expressed in E. Coli.
Specificity	This antibody recognizes Human CYP1A1. Other species ot tested.
Formulation	PBS State: Purified State: Liquid purified Ig fraction Stabilizer: 0.5% BSA Preservative: 0.05% Sodium Azide
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	58 kDa
Gene Name	cytochrome P450 family 1 subfamily A member 1
Database Link	Entrez Gene 1543 Human UniProt ID P04798
Background	This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15.
Synonyms	Cytochrome P450 1A1, Cytochrome P450-P1, Cytochrome P450 form 6, Cytochrome P450-C
Reference Data

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