Fibrillin 1 (FBN1) Mouse Monoclonal Antibody [Clone ID: 11C1.3]

Specifications

Product Data
Clone Name	11C1.3
Applications	IF, IHC
Recommend Dilution	Immunohistochemistry: 1/50-1/100 (30-60 min at RT). (See Ref.2) Immunofluorescence. (See Ref.2)
Reactivity	Bovine, Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Microfibrils from zonular apparatus of bovine eye.
Specificity	This antibody recognises Fibrillin (Mr 350 kDa).
Formulation	PBS containing 0.09% Sodium Azide as preservative. Label: FITC State: Liquid purified Ig fraction. Label: Fluorescein Isothiocyanate Isomer 1
Concentration	lot specific
Conjugation	FITC
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing.
Gene Name	fibrillin 1
Database Link	Entrez Gene 2200 Human UniProt ID P35555
Background	The fibrillins are extracellular matrix glycoproteins which occur as a major component of a subset of connective tissue microfibrils. These microfibrils have a beaded appearance and a cross-sectional diameter of 10-12 nm. In elastic tissues, these structures are thought to provide the scaffold onto which elastin is assembled to form elastic fibers, although their function in non-elastic tissues is unclear.(Ref.1) In Immunohistochemical staining of paraformaldehyde-fixed human skin, mAb 11C1.3 labels the elastic framework and more specifically the oxytalantic network close to the epidermis. The antibody also exhibits discrete staining of normal fibroblasts in culture and of extracellular (elastin) fibrils in a variety of tissues.(Ref.2,3) There is an aberrant expression of fibrillin in Marfan syndrome.(Ref.4)
Synonyms	FBN1, FBN
Reference Data

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