CD11b Rat Monoclonal Antibody [Clone ID: 3A33]

Specifications

Product Data
Clone Name	3A33
Applications	FC, IHC, IP
Recommend Dilution	Flow Cytometry (Ref.1) Immunohistochemistry on Frozen Sections. (Ref.13) Immunoprecipitation. (Ref.1)
Reactivity	Mouse
Host	Rat
Clonality	Monoclonal
Immunogen	Peritoneal macrophages from C57 B1/6 x DBA/2 F1 hybrid mice. (Ref.1)
Specificity	This antibody is specific to Alpha M subunit (Mr 170 kDa) of the CD11b/CD18 heterodimer.
Formulation	PBS without preservatives. State: Low Endotoxin State: Liquid purified Ig fraction.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Database Link	UniProt ID P05555
Background	CD11b (Integrin alpha M subunit) combines with CD18 (Integrin beta2 subunit) to form the integrin Mac-1, also known as complement receptor 3 (CR3), which mediates adhesion to C3bi and ICAM-1 (CD54). (Ref.2-6) Mac-1 is expressed at varying levels on granulocytes, macrophages, dendritic cells, NK cells, and B-1 cells in the peritoneal and pleural cavities. (Ref.2,7-10) In addition to its role in binding C3bi on opsonized targets and mediation of the subsequent ingestion process. (Ref.4,11) Mac-1 is important as an adhesion molecule in the transendothelial migration of monocytes and neutrophils. (Ref.12)
Synonyms	ITGAM, CR3A, CR-3 alpha chain, Integrin alpha-M, MAC1
Reference Data

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