Cd19 Mouse Monoclonal Antibody [Clone ID: MB19-1]

Specifications

Product Data
Clone Name	MB19-1
Applications	FC, IP
Recommend Dilution	Flow Cytometry. (Ref.1-3) Immunoprecipitation. (Ref.1)
Reactivity	Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	CD19+ mouse pre-B cell line, 300.19. (Ref.1)
Specificity	This antibody is specific to CD19 B cell differentiation antigen (Mr. 95 kDa)
Formulation	100 mM Borate Buffered Saline, pH 8.2. No preservatives or amine-containing buffer salts added. State: Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	CD19 antigen
Database Link	Entrez Gene 12478 Mouse UniProt ID P25918
Background	CD19 is a monomeric transmembrane glycoprotein expressed at relatively constant levels throughout B cell development from early pro-B/pre-B cells (i.e., B220+/CD43+/HSA+) through fully differentiated B cell stages. (Ref.1-7) Terminally differentiated plasma cells do not express CD19.1 In humans, the CD19 molecule on the surface of mature B cells associates with CD21 (CR-2) and CD81 (TAPA-1), and this multimolecular complex synergizes with surface immunoglobulin to provide signal transduction and promote cellular activation. (Ref.3,4) All splenic and peritoneal IgM+ cells of both B-1 and B-2 lineages are CD19+, with B-1 cells expressing higher levels of CD19 than B-2 cells in these sites. (Ref.1,7) Recent studies with CD19-deficient mice have suggested that this molecule may not be required for normal generation and maturation of B cells in the bone marrow. (Ref.7)
Synonyms	Leu-12, B-cell marker
Reference Data

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