Cd22 Rat Monoclonal Antibody [Clone ID: 2D6]

CAT#: AM08033LE-N

Cd22 rat monoclonal antibody, clone 2D6, Low Endotoxin



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CNY 6,072.00


货期*
4周

规格
    • 500 ug

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Specifications

Product Data
Clone Name 2D6
Applications FC, FN
Recommend Dilution Flow Cytometry.(Ref.2)
Functional Assay: Blocking of B cell homotypic adhesion. (Ref.2)
Reactivity Mouse
Host Rat
Clonality Monoclonal
Specificity This antibody is specific to CD22 (Mr 150 kDa), a B Lymphocyte Adhesion Molecule.
Formulation PBS without preservatives.
State: Low Endotoxin
State: Liquid purified Ig fraction.
Concentration lot specific
Conjugation Unconjugated
Storage Condition Store the antibody undiluted (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Gene Name CD22 antigen
Background CD22, also known as Lyb-8, is a heterodimeric transmembrane glycoprotein and a member of a structurally related group of immunoglobulin (Ig) superfamily domain-containing proteins called the sialoadhesin family. It is detected in the cytoplasm early in B cell development (late pro-B cell stage), appears on the cell surface concomitant with IgD, and is found on most IgM+IgD+ mature B lymphocytes. Expression is lost with terminal differentiation of B cells and is absent on plasma cells. Activation of B cells via cross-linking of surface Ig increases CD22 expression. (Ref.1,2) CD22 associates with the B cell receptor (BCR) complex and mediates intercellular adhesion. (Ref.2-4) Its intracellular domain is phosphorylated after antigen receptor crosslinking and is involved in negative regulation of B-cell activation. (Ref.6-9)
Synonyms SIGLEC2, Siglec-2, B-cell receptor CD22, Leu-14, BL-CAM
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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