CD45 / LCA (CD45RB) Rat Monoclonal Antibody [Clone ID: C363.16A]

Specifications

Product Data
Clone Name	C363.16A
Applications	FC
Recommend Dilution	Flow Cytometry. < / = 1 µg/10e6 cells. (Ref.1-3)
Reactivity	Mouse
Host	Rat
Clonality	Monoclonal
Immunogen	Cloned mouse Th2 cell lines. (Ref.1)
Specificity	This antibody is specific to an exon B-dependent epitope of CD45 glycoprotein.
Formulation	PBS containing 0.09% Sodium Azide as preservative. Label: Biotin State: Liquid purified Ig fraction.
Concentration	lot specific
Conjugation	Biotin
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	protein tyrosine phosphatase, receptor type, C
Database Link	Entrez Gene 19264 Mouse UniProt ID P06800
Background	CD45RB is an isoform of CD45 with exon 5 splicing (encodes B determinant). It is a 220 kD glycoprotein expressed on peripheral B cells, naïve T cells, thymocytes, weakly on macrophages, and dendritic cells. It plays a critical role in TCR and BCR signaling. As T cells become activated and progress from naïve to memory cells, CD45RB expression is downregulated. Additionally, functionally distinct CD4 T cell subsets, which secrete differing cytokine profiles, can be separated by CD45RB intensity. The primary ligands for CD45 are galectin-1, CD2, CD3, CD4 and Thy-1. Distribution: Peripheral B cells, naïve T cells, most thymocytes, low density on macrophages and dendritic cells. Function: Phosphatase, T cell development and activation Structure: Phosphatase receptor (CD45 gene exon 5), 220 kD
Synonyms	PTPRC, Leukocyte common antigen, L-CA, T200
Reference Data

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