Tfrc Rat Monoclonal Antibody [Clone ID: RI7217]

Specifications

Product Data
Clone Name	RI7217
Applications	FC
Recommend Dilution	Flow Cytometry: < / = 1 µg/10e6 cells (Reported in literature)
Reactivity	Mouse
Host	Rat
Clonality	Monoclonal
Specificity	This antibody recognises CD71/Transferrin Receptor, Mr 180-190 kDa (90-95 kDa under reducing conditions).
Formulation	PBS containing 0.09% Sodium Azide as preservative. Label: Biotin State: Liquid purified Ig fraction.
Concentration	lot specific
Conjugation	Biotin
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	transferrin receptor
Database Link	Entrez Gene 22042 Mouse UniProt ID Q62351
Background	CD71, a type II transmembrane glycoprotein expressed on the cell surface as a homodimer, is the Transferrin Receptor. It is essential for the growth of normal and neoplastic cells. It is expressed at low levels on resting B and T lymphocytes but is upregulated during responses to antigens and mitogens, presumably reflecting the iron dependence of proliferation. Its expression declines with maturation and differentiation. CD71 plays a critical role in cell proliferation by controlling the supply of iron, which is essential for many metabolic pathways, through the binding and endocytosis of transferrin, the major ironcarrying protein. It may also be involved in signal transduction via its association with the T cell receptor zeta chain. Clone RI7217 inhibits cell proliferation in vitro.
Synonyms	TfR1, p90, Transferrin receptor protein 1
Reference Data

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