Cd86 Rat Monoclonal Antibody [Clone ID: GL1]

CAT#: AM08053LE-N

Cd86 rat monoclonal antibody, clone GL1, Low Endotoxin



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CNY 4,928.00


货期*
4周

规格
    • 500 ug

Product images

Specifications

Product Data
Clone Name GL1
Applications FC
Recommend Dilution Flow Cytometry. (Ref.1-7)
Immunoprecipitation. (Ref.1)
Immunohistochemistry Frozen Sections. (Ref.6)
Functional Assays: In vivo and In vitro blocking assays. (Ref.1,3,5)
Reactivity Mouse
Host Rat
Clonality Monoclonal
Immunogen LPS-activated mouse B cells.(Ref.1)
Specificity This antibody recognises CD86, the B7-2 co-stimulatory molecule and a ligand for CD28 and CD152/CTLA-4.
The monoclonal antibody GL1 blocks mixed lymphocyte reactions and stimulation of T cells by antigen-presenting cells. (Ref.1,3,5)
Formulation PBS without preservatives.
State: Low Endotoxin
State: Liquid purified Ig fraction.
Concentration lot specific
Conjugation Unconjugated
Storage Condition Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Gene Name CD86 antigen
Background CD86 (also known as B7-2) is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is expressed at high levels on resting peripheral monocytes and dendritic cells and at very low density on resting B and T lymphocytes. (Ref.1-5) CD86 expression is rapidly upregulated by B-cell specific stimuli with peak expression at 18-42 hours after stimulation. (Ref.1,5) CD86, along with CD80/B7-1, is an important accessory molecule in T cell costimulation via its interaction with CD28 and CD152/CTLA-4. Since CD86 has rapid kinetics of induction, it is believed to be the major CD28 ligand expressed early in the immune response. (Ref.1-9).
Synonyms CD28LG2, Activation B7-2 antigen, B70, BU63, B7.2, FUN-1
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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