T Cell Receptor (TCR) gamma/delta Hamster Monoclonal Antibody [Clone ID: UC7-13D5]

Specifications

Product Data
Clone Name	UC7-13D5
Applications	FC
Recommend Dilution	Flow Cytometry. This clone as has also been described to work in Immunoprecipitation, In vitro Activation of gamma-delta TCR-bearing cells and In vivo Depletion of gamma-delta TCR-expressing T cells. (Bluestone, J.A., et al. 1991. Immunol. Rev. 120:5).
Reactivity	Mouse
Host	Hamster
Clonality	Monoclonal
Specificity	This Monoclonal antibody is specific to the gamma-delta heterodimer and plate-bound UC7-13D5 activates gamma-delta TCR-bearing cells. It does not react with alpha-beta TCR-expressing T cells. (Davis, M.M. 1990. Annu. Rev. Biochem. 59:475. Allison, J.P., and W.L. Havran. 1991. Annu. Rev. Immunol. 9:679. Klausner, R.D., and L.E. Samuelson. 1991. Cell 64:875. Dent, A.L., et al. 1990. Nature 343:714.)
Formulation	PBS containing no preservatives. State: Low Endotoxin State: Liquid purified Ig fraction.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted (in aliquous) at -20°C. Avoid repeated freezing and thawing.
Background	T cell receptors (TCR) recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. The TCR gamma/delta heterodimer of the CD3/T-cell receptor complex is clonotypic and consists of Ig-like variable and constant domains. (Ref.1) It is expressed during thymopoiesis and on the small subpopulation of gamma/delta TCR expressing T lymphocytes in the periphery. The majority of T cells present in some epithelial tissues are gamma/delta+ and have limited receptor diversity. (Ref.1,2) The TCR gamma/delta heterodimer recognizes peptide antigen bound to MHC antigens, and subsequent signal transduction mediated by the invariant chains leads to T cell activation. (Ref.3)
Synonyms	TCRG, TCRD, T-Cell Receptor gamma, T-Cell Receptor delta, T-Cell Receptor gamma delta
Reference Data

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