Ctla4 Hamster Monoclonal Antibody [Clone ID: 1B8]

Specifications

Product Data
Clone Name	1B8
Applications	FC, FN, IP
Recommend Dilution	Flow Cytometry. (Ref.1,2) Immunoprecipitation. (Ref.1) In vitro Functional Studies. (Ref.1,2) Enhancement of tumor immunity. (Ref.3)
Reactivity	Mouse
Host	Hamster
Clonality	Monoclonal
Specificity	This Monoclonal antibody is specific to CD152/CTLA-4.
Formulation	100 mM Borate Buffered Saline, pH 8.2. No preservatives or amine-containing buffer salts added. State: Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	cytotoxic T-lymphocyte-associated protein 4
Database Link	Entrez Gene 12477 Mouse UniProt ID P09793
Background	The lymphocyte surface antigen CD152, also known as CTLA-4, is related to the co-stimulatory molecule CD28, and both molecules share common B7 family counter-receptors. (Ref.1-4) However CD152 is thought to be a negative regulator of T cell activation (Ref.1-3) and may play a role in apoptotic control of T cells. CD152 exists as a 69 kDa homodimer (Ref.1), and is relatively conserved among Humans, Mice and Chickens. (Ref.2)
Synonyms	CTLA-4
Reference Data

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