Klra3 Hamster Monoclonal Antibody [Clone ID: 14B11]

Specifications

Product Data
Clone Name	14B11
Applications	FC
Recommend Dilution	Flow Cytometry: < / = 1 µg/10e6 cells. (Ref.1,3)
Reactivity	Mouse
Host	Hamster
Clonality	Monoclonal
Specificity	This antibody is specific to an epitope common to the Ly49C, Ly49F, Ly49H and Ly49I allelic/splice variants. The antibody stains ~ 90% of NK1.1+CD3- splenocytes, and ~ 6% of CD8+ spleen cells from C57BL/6 mice. (Ref.1) The antibody also stains 30-80% of NK1.1+CD3-splenocytes in other mouse strains tested (BALB/c, C3H, 129, SJL, AKR/J).
Formulation	PBS containing 0.09% Sodium Azide as preservative. Label: Biotin State: Liquid purified Ig fraction.
Concentration	lot specific
Conjugation	Biotin
Storage Condition	Store the antibody undiluted at 2-8°C for one month or in (aliquots) at -20°C for longer. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing.
Gene Name	killer cell lectin-like receptor, subfamily A, member 3
Database Link	Entrez Gene 16640 MouseEntrez Gene 16634 Mouse UniProt ID Q64329
Background	Ly49C, Ly49F, Ly49H and Ly49I are members of the lectin like homodimeric Ly49 family of cell surface receptors. Mouse Ly49 receptors exhibit allelic specificity for MHC class I Ia molecules and are thought to serve to prevent natural killer (NK) cells from attacking normal cells, while allowing them to attack infected or transformed cells in which class I molecules have been down regulated. (Ref.2) These inhibitory receptors are also expressed on a subpopulation of mouse CD8+ T cells.
Synonyms	Ly49C, Ly49F, Ly49H, Ly49I, Ly-49H, Ly-49C, Ly-49F, Ly-49I, Klra3, Klra9, Klra8, Klra6
Reference Data

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