Itgb7 Rat Monoclonal Antibody [Clone ID: DATK32]

Specifications

Product Data
Clone Name	DATK32
Applications	FC
Recommend Dilution	Flow Cytometry: < / = 1 µg/10e6 cells. (Ref.1-4)
Reactivity	Mouse
Host	Rat
Clonality	Monoclonal
Immunogen	AKR/Cum mouse spontaneous T lymphoma cell line TK1. (Ref.1)
Specificity	This antibody is specific to mouse LPAM1 (Integrin alpha 4 beta 7). It recognises a conformational epitope on the heterodimer.
Formulation	PBS containing 0.09% Sodium Azide as preservative. Label: Biotin State: Liquid purified Ig fraction.
Concentration	lot specific
Conjugation	Biotin
Storage Condition	Store the antibody undiluted at 2-8°C for one month or in (aliquots) at -20°C for longer. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing.
Gene Name	integrin beta 7
Database Link	Entrez Gene 16421 Mouse UniProt ID P26011
Background	The lymphocyte Peyer’s patch adhesion molecule (LPAM-1), also known as Integrin alpha 4 beta 7 is a member of the integrin family of cell surface receptors. It is expressed primarily on mucosal lymphocytes, but is also present on NK cells and eosinophils. The alpha 4 beta 7 heterodimer mediates the binding of lymphocytes to its ligand, mucosal vascular addressin (MAdCAM1) on the high endothelial venules, thereby directing the homing of lymphocytes into Peyer's patches and intestinal lamina propria. (Ref.1-4) The Monoclonal antibody DATK32 has been shown to be useful for studies of the induction of homotypic cellular aggregation and the blockade of binding to cell adhesion molecules. (Ref.1)
Synonyms	Integrin beta-P, M290 IEL antigen, ITGB7, LPAM-1, LPAM1
Reference Data

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