MHC Class II I-Ab Rat Monoclonal Antibody [Clone ID: NIMR-4]

Specifications

Product Data
Clone Name	NIMR-4
Applications	FC, FN
Recommend Dilution	Flow Cytometry. Complement-dependent Cytotoxicity Assays.
Reactivity	Mouse
Host	Rat
Clonality	Monoclonal
Specificity	Specific to MHC Class II molecules. This antibody reacts specifically with a non-polymorphic I-A-encoded epitope on MHC Class II antigens. Class II antigens are predominantly expressed on antigen-presenting cells including B lymphocytes, macrophages, dendritic cells and certain epithelial cells.
Formulation	PBS without preservatives. State: Low Endotoxin State: Liquid purified Ig fraction.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Database Link	UniProt ID P18468
Background	MHC Class II antigens are heterodimers consisting of one alpha chain(31-34kD) and one beta chain (26-29kD). The family of monoclonal antibodies (ER-TR 3, ER-TR 2, ER-TR 1) detect MHC class II antigens encoded by the murine Ia region of the H-2 complex, corresponding to the human HLA-DR region. MHC Class II antigens are a valuable tool for studying T helper cell interaction with class II positive antigen presenting cells (dendritic cells, B cells, macrophages) and offer new possibilities for studying the development of T helper cells since these antibodies also stain stromal cells in the thymus. MHC Class II antigens are also inducible on a number of other cells (endothelium and epithelial cells) by interferon gamma.
Synonyms	H2-Eb1, H-2 class II histocompatibility antigen I-A beta chain
Reference Data

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