Il2rb Rat Monoclonal Antibody [Clone ID: 5H4]

Specifications

Product Data
Clone Name	5H4
Applications	FC, IP
Recommend Dilution	Flow Cytometry. (Ref.1) Immunoprecipitation. (Ref.1)
Reactivity	Mouse
Host	Rat
Clonality	Monoclonal
Immunogen	Rat myeloma YB2/0 transfected with truncated mouse IL-2RB cDNA. (Ref.1)
Specificity	This antibody recognises beta chain (Mr. 90-100 kDa) of the IL-2 Receptor. It does not block IL-2 binding. (Ref.1)
Formulation	PBS without preservatives. State: Low Endotoxin State: Liquid purified Ig fraction.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	interleukin 2 receptor, beta chain
Database Link	Entrez Gene 16185 Mouse UniProt ID P16297
Background	The IL-2 receptor is a complex of three distinct polypeptide chains: (i) the alpha chain which binds IL-2 with low affinity; (ii) the beta chain that binds IL-2 with high affinity; and (ii) the common gamma chain (gc) that does not bind IL-2. (Ref.2) The high affinity receptor complex is an alpha/beta/gamma heterotrimer with a Kd of 1.3 x 10e-11 M. (Ref.2) In mouse spleen, CD122 is expresed on ~30% of CD8+ cells and all NK cells, but < 1% of B cells and CD4+ T lymphocytes. In the thymus, its expression is confined to CD4-CD8+ single positive and CD4-CD8- double negative cells. (Ref.4) Cytoplasmic regions of the IL-2R beta chain are involved in IL-2-mediated cellular signaling and, via the interaction of IL-2 and its receptor complex, may be involved in the generation and differentiation of T lymphocytes. (Ref.1,4)
Synonyms	Interleukin-2 receptor subunit beta, IL-2 receptor subunit beta, IL2 Receptor beta, P70-75
Reference Data

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