MHC Class I H-2 Kk Mouse Monoclonal Antibody [Clone ID: 16-3-22S]

Specifications

Product Data
Clone Name	16-3-22S
Applications	CT, FC, IHC
Recommend Dilution	Flow Cytometry. (Ref.1) Immunohistochemistry (Acetone-Fixed, Frozen Sections only). Complement-mediated Cytotoxicity. (Ref.1)
Reactivity	Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	C3H.SW mouse splenocytes.
Specificity	This antibody reacts with the H-2Kk MHC class I alloantigen. Cross-reactivity with splenocytes of SJL/Hsd mice has been observed by flow cytometric analysis. (Ref.2) It does not react with other (e.g., b, d, q) haplotypes.
Formulation	100 mM Borate Buffered Saline, pH 8.2. No preservatives or amine-containing buffer salts added. State: Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Database Link	UniProt ID P04223
Background	MHC Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. MHC class I antigens are heterodimers consisting of one alpha chain (44kDa) with beta2- microglobulin (11.5 kDa). The antigen is expressed by all somatic cells at varying levels. Lymphocytes are highly positive whereas fibroblasts or neurons show only a low level of antigen.
Synonyms	H2-K1, H2-K, H-2K(K)
Reference Data

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