CD28 Mouse Monoclonal Antibody [Clone ID: AV7]
CAT#: AM08121BT-N
CD28 mouse monoclonal antibody, clone AV7, Biotin
Conjugation: Unconjugated FITC PE
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CNY 5,841.00
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Specifications
Product Data | |
Clone Name | AV7 |
Applications | FC |
Recommend Dilution | Flow Cytometry: < / = 1 µg/10e6 cells. (Ref.1) |
Reactivity | Chicken |
Host | Mouse |
Clonality | Monoclonal |
Specificity | This antibody recognizes Chicken CD28, a monomeric molecule of Mr 40-44 kDa with 50% amino acid sequence identity with mammalian CD28. |
Formulation | PBS containing 0.09% Sodium Azide as preservative. Label: Biotin State: Liquid purified Ig fraction. |
Concentration | lot specific |
Conjugation | Biotin |
Storage Condition | Store the antibody undiluted at 2-8°C for one month or in (aliquots) at -20°C for longer. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing. |
Gene Name | CD28 molecule |
Database Link | |
Background | Chicken CD28 antigen is a type I transmembrane monomeric glycoprotein which does not contain the cysteine residues that form disulfide-linked covalent homodimers found in the mammalian counterpart. This may reduce the avidity of binding to individual ligand molecules expected to be present on Ag presenting cells. Peripheral gamma/delta+ T cells are CD28-negative. (Ref.1) Monoclonal antibodies against CD28 have a costimulatory effect on T cells stimulated by phorbol myristate acetate (PMA), concanavalin A or MAbs against the avian T cell receptor (TCR). Both Vbeta1- and Vbeta2-expressing cells respond equally well to stimulation with anti-CD28 in combination with PMA. These responses are resistant to cyclosporin A, but inhibited by herbimycin A, suggesting that CD28 employs a signalling pathway at least partly distinct from that triggered by TCR/CD3. (Ref.2) |
Synonyms | TP44 |
Reference Data |
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