MHC Class I Mouse Monoclonal Antibody [Clone ID: F21-2]

Specifications

Product Data
Clone Name	F21-2
Applications	FC, IHC, IP, WB
Recommend Dilution	Flow Cytometry (Ref.1-4). Immunoprecipitation (Ref.1-3). Immunohistochemistry on Frozen Sections. Western Blot. Immunoaffinity Chromatography.
Reactivity	Chicken
Host	Mouse
Clonality	Monoclonal
Specificity	This antibody recognizes a monomorphic epitope on avian MHC Class I molecules (Mr ~ 68 kDa). It also reacts with Turkey MHC Class I.
Formulation	100 mM Borate Buffered Saline, pH 8.2. No preservatives or amine-containing buffer salts added. State: Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Background	MHC Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. MHC class I antigens are heterodimers consisting of one alpha chain (44kDa) with beta 2 microglobulin (11.5 kDa). The antigen is expressed by all somatic cells at varying levels. MHC Class I molecules are expressed on most nucleated cells where they present endogenously synthesized antigenic peptides to CD8+ T lymphocytes, which are usually cytotoxic T cells. (Ref.1-3)Fibroblasts or neurons however only show a low level of antigen.
Synonyms	MHC Class 1, HLA Class 1
Reference Data

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