KIT Mouse Monoclonal Antibody [Clone ID: kit2c75]

Specifications

Product Data
Clone Name	kit2c75
Applications	FC
Recommend Dilution	Flow Cytometry: < / = 1 µg/10e6 cells. (Ref.6-10)
Reactivity	Chicken
Host	Mouse
Clonality	Monoclonal
Immunogen	Sp2/0 cells, Sp/chkit4A4, transfected with Chicken c-kit cDNA.
Specificity	This antibody recognizes Chicken c-Kit.
Formulation	PBS containing 0.09% Sodium Azide as preservative. Label: Biotin State: Liquid purified Ig fraction.
Concentration	lot specific
Conjugation	Biotin
Storage Condition	Store the antibody undiluted at 2-8°C for one month or in (aliquots) at -20°C for longer. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing.
Gene Name	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Database Link	Entrez Gene 378783 Chicken UniProt ID Q08156
Background	c-Kit is a transmembrane tyrosine kinase encoded by the cKit proto oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Mutations in c-Kit have been found to be important for tumor growth and progression in a variety of cancers including mast cell diseases, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma and lung cancer. Phosphorylation at tyrosine 721 of c-Kit allows binding and activation of PI3 kinase.
Synonyms	SCFR, KIT
Reference Data

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