CD51 (ITGAV) Mouse Monoclonal Antibody [Clone ID: 13C2]

Specifications

Product Data
Clone Name	13C2
Applications	FC, IHC
Recommend Dilution	Flow Cytometry: ≤ 1 µg/106 cells (Reported in literature 7,9,10). Immunohistochemistry on Frozen Sections (Reported in literature 1,5). Immunocytochemistry (Reported in literature 3). Immunoprecipitation (Reported in literature 2,3,5,9). ELISA (Reported in literature 8). Purification (Reported in literature 4,5). Depletion (Reported in literature 7). Blocking (Reported in literature 3,6). Adhesion (Reported in literature 3).
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Cell suspension containing osteoclasts from osteoclastomas.
Specificity	This antibody recognizes CD51.
Formulation	100 mM Borate Buffered Saline, pH 8.2. No preservatives or amine-containing buffer salts added. State: Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C.
Gene Name	integrin subunit alpha V
Database Link	Entrez Gene 3685 Human UniProt ID P06756
Background	Integrin alpha V chain interacts with the integrin beta 3 subunit/CD61 to form the alpha-V-beta-3 heterodimer/vitronectin receptor. It is expressed on endothelial cells, some activated leukocytes, NK cells, macrophages, neutrophils, and platelets. Integrin alpha V also forms heterodimers with the integrin beta 1, beta 5, beta 6, and beta 8 subunits. Alpha-V-beta-3 is an activation dependent receptor for platelet attachment and spreading on vitronectin and other matrix components. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. Alpha-V/beta-6 binds to foot-and-mouth disease virus (FMDV) VP1 protein and acts as a receptor for this virus By similarity. Alpha-V/beta-6 binds to coxsackievirus A9 and coxsackievirus B1 capsid proteins and acts as a receptor for these viruses. It also mediates leukocyte-endothelial cell adhesion via interaction with CD31. (Ref.1-4)
Synonyms	Integrin alpha-V, MSK8, VNRA, Vitronectin receptor subunit alpha
Reference Data

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