MMP1 Mouse Monoclonal Antibody [Clone ID: SB12e]

Specifications

Product Data
Clone Name	SB12e
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA: 1/3,000-1/8,000. Western Blot. Immunohistochemistry (Frozen/Paraffin): ≤ 2 µg/ml.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant MMP-1.
Specificity	This antibody is specific for Human MMP-1. Does not cross react with Human MMP-2, MMP-3 or MMP-9. Other species not tested.
Formulation	100 mM Borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added. State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	matrix metallopeptidase 1
Database Link	Entrez Gene 4312 Human UniProt ID P03956
Background	The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane bound zincendopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc binding site characterizes the structure of the MMPs. In addition, fibronectin like repeats, a hinge region, and a C terminal hemopexin like domain allow categorization of MMPs into the collagenase, gelatinase, stomelysin and membrane type MMP subfamilies. All MMPs are synthesized as proenzymes, and most of them are secreted from the cells as proenzymes. Thus, the activation of these proenzymes is a critical step that leads to extracellular matrix breakdown. MMPs are considered to play an important role in wound healing, apoptosis, bone elongation, embryo development, uterine involution, angiogenesis and tissue remodeling, and in diseases such as multiple sclerosis, Alzheimer's, malignant gliomas, lupus, arthritis, periodontis, glumerulonephritis, atherosclerosis, tissue ulceration, and in cancer cell invasion and metastasis. MMP1, also known as interstitial collagenase, is the only enzyme that is able to initiate the breakdown of the interstitial collagens, types I, II, and III
Synonyms	Interstitial collagenase, Matrix metalloproteinase-1, Fibroblast collagenase, MMP1, CLG
Note	Predicted Molecular Weight: 54 kDa.
Reference Data

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