MMP9 Mouse Monoclonal Antibody [Clone ID: SB15c]

Specifications

Product Data
Clone Name	SB15c
Applications	ELISA, IHC
Recommend Dilution	ELISA: ≤ 1 µg/ml. Immunohistochemistry on Frozen Sections. Immunohistochemistry-Paraffin Sections (Ref-1-3). Immunoblotting (Reported in literature, See also Ref.4).
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant full length MMP-9.
Specificity	This antibody is specific for Human MMP-9. Does not cross react to Human MMP-1, MMP-2 or MMP-3.
Formulation	100 mM Borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added. State: Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	matrix metallopeptidase 9
Database Link	Entrez Gene 4318 Human UniProt ID P14780
Background	MMP9, also known as gelatinase B, is a secreted enzyme which degrades the interstitial collagens, types I, II, and III and is produced by normal alveolar macrophages and granulocytes. The expression of MMP9 increases in Epstein-Barr virus infected lymphoma derived cell lines and may be of significance in typically invasive nasopharyngeal carcinomas. MMP9 is constitutively produced by some tumor cell lines (e.g.: HT1080, HL60, U937) but not by most quiescent cells and tissues. Treatment of cells with the phorbol ester TPA stimulates production of MMP9 in some cell types, but the low protein levels produced (pg/ml) often require concentration of cell culture media to visualize the bands by Western blotting.
Synonyms	Matrix metalloproteinase-9, MMP9, 92 kDa type IV collagenase, 92 kDa gelatinase, GELB, Gelatinase B, CLG4B
Reference Data
Protein Families	Druggable Genome, Protease
Protein Pathways	Bladder cancer, Leukocyte transendothelial migration, Pathways in cancer

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