CD147 (BSG) Mouse Monoclonal Antibody [Clone ID: MEM-M6/2]

Specifications

Product Data
Clone Name	MEM-M6/2
Applications	FC, IHC
Recommend Dilution	Flow Cytometry. Immunohistochemistry on Paraffin Sections: 10 µg/ml.
Reactivity	Human, Porcine
Host	Mouse
Clonality	Monoclonal
Immunogen	A soluble recombinant form of CD147, CD147Rg, which consists of the cDNA coding for the entire extracellular region of CD147 fused to the DNA coding for the hinge region, CH2 and CH3 domain of human IgG1
Specificity	AM08322PU-N recognizes extracellular Ig domain D1 of CD147 (Neurothelin), a 50-60 kDa type I transmembrane glycoprotein primarily expressed on all leukocytes, red blood cells, platelets and endothelial cells; it is not expressed by resting lymphocytes. This antibody is a high-affinity antibody capable of binding to unstimulated peripheral blood T cells.
Formulation	PBS, pH 7.4 containing 15 mM Sodium Azide as preservative State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein A Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	basigin (Ok blood group)
Database Link	Entrez Gene 682 Human UniProt ID P35613
Background	CD147 plays a pivotal role in spermatogenesis, embryo implantation, neural network formation and tumor progression. It stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). CD147 may target monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. CD147 also seems to be a receptor for oligomannosidic glycans. In vitro, it promotes outgrowth of astrocytic processes. CD147 forms homooligomers in a cis-dependent manner on the plasma membrane. It forms a complex with MMP1 at the tumor cell surface. CD147 interacts with SLC16A1 and SLC1A3; probably a BSG dimer is associated with a monocarboxylate transporter dimer. CD147 also interacts with ATP1B2, MAG and L1CAM.
Synonyms	Basigin, BSG, EMMPRIN, TCSF
Reference Data

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.