Endostatin (COL18A1) (full length) Mouse Monoclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Immunohistochemistry on Paraffin Sections: 1/100. Western Blot.
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Full-length Recombinant Murine Endostatin
Specificity	Recognizes Mouse Endostatin (Mr 22kD), an unidentified protein is also weakly detected (Mr 54kD).
Formulation	50 mM Sodium Phosphate, pH 8.0 containing 0.05% Sodium Azide, before the addition of Glycerol to 30% State: Purified State: Liquid purified Ig fraction
Purification	Thiophilic Adsorption Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	collagen type XVIII alpha 1 chain
Database Link	Entrez Gene 80781 Human UniProt ID P39060
Background	Endostatin (20-22 kDa), a cleaved product of the C-terminal domain of collagen XVIII, is an endogenous angiogenesis inhibitor. It was originally found in conditioned media from a murine endothelial tumor cell line, hemangioendothelioma. Endostatin inhibits endothelial cell migration (in vivo and in vitro) and induces endothelial cell apoptosis. It inhibits tumor growth and impairs blood vessel maturation in wound healing. Endostatin has an important role in endothelial cell adhesion and cytoskeletal organization. Endostatin can be found in vessel walls (elastic fibers) and basement membranes.
Synonyms	COL18A1, Endostatin, KNO1
Reference Data

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