IL33 Mouse Monoclonal Antibody [Clone ID: 4E9]

Specifications

Product Data
Clone Name	4E9
Applications	ELISA, WB
Recommend Dilution	ELISA. Western blot (1:500 - 1:2,000).
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human IL-33 (112-270 aa) purified from E. coli
Specificity	The antibody recognizes human IL-33. Other species not tested.
Formulation	PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein-G affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	interleukin 33
Database Link	Entrez Gene 90865 Human UniProt ID O95760
Background	Interleukin 33 (IL-33) is a 32 kDa proinflammatory cytokine and intracellular nuclear factor with transcriptional regulatory properties. IL-33 is structurally related to IL-1, which induces helper T-cells to produce type 2 cytokines and acts through the receptor IL1RL-1 (IL1 receptor-like-1), which is known also as ST2. Binding of IL-33 to this receptor activates NF-kappa-B and MAP kinases and induces in vitro Th2 cells to produce cytokines. In vivo, IL-33 induces expression of IL-4, IL-5, IL-13 and leads to severe pathological changes in mucosal organs and in vitro, it can be divided to N-terminal fragment of 12 kDa and C-terminal fragment of 18kDa by cleavage of caspase-1.
Synonyms	IL-33, IL1F11, IL-1F11, NFHEV, NF-HEV, C9orf26
Reference Data

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