alpha Synuclein (SNCA) (also beta reactive) Mouse Monoclonal Antibody [Clone ID: 3B6]

Specifications

Product Data
Clone Name	3B6
Applications	ELISA, FC, IF, WB
Recommend Dilution	ELISA. Western blot (1/1,000-1/2,000). Flow Cytometry. Immunofluorescence.
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human α-synuclein (119-140aa) purified from E. coli
Specificity	The antibody recognizes α,β - Synuclein.
Formulation	PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein-G affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	synuclein alpha
Database Link	Entrez Gene 6622 Human UniProt ID P37840
Background	α-synuclein (amino acids 119-140), an acidic neuronal protein of 140 amino acids, is extremely heat-resistant and is natively unfolded with an extended structure primarily composed of random coils. α-synuclein has been suggested to be implicated in the pathogenesis of Parkinson's disease and related neurodegenerative disorders, and more recently, to be an important regulatory component of vesicular transport in neuronal cells. Specially, the non-Aβ component of amyloid plaques is a highly amyloidogenic peptide consisting of 35 amino acids which was first identified associated with senile plaques in the Alzheimer's disease brain.
Synonyms	NACP, PARK1
Reference Data

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