Plakophilin 3 (PKP3) Mouse Monoclonal Antibody [Clone ID: PKP3-270.6.2]

Specifications

Product Data
Clone Name	PKP3-270.6.2
Applications	IF, IHC, WB
Recommend Dilution	Immunoblotting: 1/500 ECL method. Immunofluorescence. Immunohistochemistry on frozen sections: Ready-to-use.
Reactivity	Bovine, Human, Mouse, Xenopus
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant protein (E. coli) of human plakophilin 3
Specificity	This antibody reacts to Plakophilin 3. Positive tissues and culture cells: - stratified squamous epithelia: palmar, epidermis, scalp skin - stratified epithelia: tongue, vagina, esophagus - transitional epithelia: bladder - non-stratified epithelia: colon, duodenum, pancreas, several glands - non-epithelial: reticulum cells of lymph node follicle - HaCaT, MCF7, HeLa, HT-29, CaCo 2, Caski, BMGE, MDCK and other Negative tissues and cell lines: - liver, heart, skeletal muscle, endothelia (vessels) - PLC, RD, SV80, HL60, Raji, Jok1, Glioma, K562, 3T3L1, A6, PtK2
Formulation	State: Supernatant State: Liquid culture supernatant
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	plakophilin 3
Database Link	Entrez Gene 56460 MouseEntrez Gene 11187 Human UniProt ID Q9Y446
Background	Plakophilin 3 is an Armadillo-like protein present in nuclei and desmosomes of epithelial cells. The expression pattern of this protein seems to be largely restricted to epithelial cell types. Plakophilin-3 can be detected along cell borders in a punctuate staining pattern typical for desmosomal proteins. In addition to the desmosomal immunolocalisation, immunostaining was observed as bright nuclear speckles. Thus, like plakophilin-1 and-2, plakophilin-3 displays a dual intracellular localisation in the desmosomal plaque and in the cell nucleus, and therefore is probably involved in signal transduction pathways between the plasma membrane and the nucleus. The human protein has a predicted molecular mass of 87 kD.
Synonyms	Plakophilin-3
Reference Data

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