Plakophilin 4 (PKP4) (Multi-Epitope Cocktail) Mouse Monoclonal Antibody [Clone ID: p0071 (406.3.1/ 433.10.3/7.7.9)]

Specifications

Product Data
Clone Name	p0071 (406.3.1/ 433.10.3/7.7.9)
Applications	IF, IHC, WB
Recommend Dilution	Immunoblotting (1/10-1/50). Immunofluorescence (undiluted). Immunohistochemistry on Frozen Sections (undiluted). Immunohistochemistry on Paraffin Sections (undiluted). Positive Control: MCF-7 cells. Incubation Time: 1-1.5 hour at RT.
Reactivity	Bovine, Human, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Synthetic peptides of human p0071 also described as plakophilin-4
Specificity	Detects a plaque protein (p0071) specific for a subtype of adherens junctions, with a Molecular Mass of 135 kD and is closely related to neurojungin / delta-catenin and ARVC (all belonging to the p120 armadillo subfamily). p0071 is specifically detected in the plaques of the composite junctions (area compositae) of cardiac intercalated disks, in puncta adhaerentia of single- and multi-layered epithelia and blood vessel endothelial cells.; it is, however, absent from desmosomes. Reactivities on Cultured Cell Lines (tested so far): MCF-7, A431, CaCo-2, HT-29, PLC, 16HBE14o, HaCaT, SV80, U333 CG, 3T3, RVF-SMC, MH1C1.
Formulation	State: Supernatant State: Liquid culture supernatant containing 0.09% Sodium azide
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	plakophilin 4
Database Link	Entrez Gene 8502 Human UniProt ID Q99569
Background	Plakophilin 4 (PKP4) is an Armadillo-like protein, characterized by a series of armadillo repeats. It is a component of desmosomal plaques and may play a role in junctional plaque organization.
Synonyms	PKP4, p0071
Reference Data

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