FPRL1 (FPR2) (C-term) Mouse Monoclonal Antibody [Clone ID: C4F9]

Specifications

Product Data
Clone Name	C4F9
Applications	ELISA, WB
Recommend Dilution	ELISA: Reactive to the C-terminal amino acid sequence (SASPPAETELQAM) on FPRL1 in indirect ELISA. Western Blot (1/1000).
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	A short peptide corresponding to the C-terminal amino acid sequence (SASPPAETELQAM) on FPRL1
Specificity	This monoclonal antibody reacts with the above mentioned peptide in ELISA and reacts with the 38KDa FPRL1 on Western Bloton.
Formulation	0.01M PBS, pH 7.2 without preservatives State: Purified State: Lyophilized purified IgG fraction
Reconstitution Method	Restore with Double distillated water to adjust the final concentration to 1.0 mg/ml
Purification	Affinity Chromatography
Conjugation	Unconjugated
Storage Condition	Upon receipt, store (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	formyl peptide receptor 2
Database Link	Entrez Gene 2358 Human UniProt ID P25090
Background	Human formyl peptide receptor-like 1(FPRL1) is a G-protein coupled seven transmembrane receptor. The receptor can bind to the formyl peptides derived from the degradation of the cell wall of infected bacteria and host cells. FPRL1 expressed on the cell surface of neutrophils and other leukocytes mediates the chemotaxis of these cells toward infected site. It has been reported that acute phase protein SAA is also a ligand of FPRL1 and SAA can induce the secretion of IL-8 and TNF-α by neutrophil through FPRL1 signalling. FPRL1 has also been shown to mediate the chemotaxis of microglia by Abeta42 peptide and the internalization of Abeta42 peptide into cytoplasma of macrophage, indicating that FRPL1 may participate in the Abeta42 peptide elicited pathogenesis in Alzheimer’s disease.
Synonyms	N-formyl peptide receptor 2, FMLP-R-I, FPRH1, RFP, LXA4R
Reference Data
Protein Families	Druggable Genome, GPCR, Transmembrane
Protein Pathways	Neuroactive ligand-receptor interaction

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