SHP1 (PTPN6) Mouse Monoclonal Antibody [Clone ID: PTY11]

Specifications

Product Data
Clone Name	PTY11
Applications	ELISA, IF, IHC, WB
Recommend Dilution	ELISA. Western Blot. Immunocytochemistry.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant protein corresponding to full-length PTP1-C
Specificity	This antibody recognizes single 67kDa PTP1-C in Human cells that express the enzyme and the SH2(C) domain.
Formulation	0.01M PBS, pH 7.2 without preservatives State: Purified State: Lyophilized purified IgG fraction
Reconstitution Method	Restore with Double distillated water to adjust the final concentration to 1.0 mg/ml.
Purification	Affinity chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Upon receipt, store (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	protein tyrosine phosphatase, non-receptor type 6
Database Link	Entrez Gene 5777 Human UniProt ID P29350
Background	The phosphorylation state of receptors and signal transduction molecules influences almost every cell activities. The phosphorylation rate is regulated by kinases which add phosphate group and by phosphatases which remove phosphate group form the amino acid residues on protein molecules. Protein tyrosine phosphatase 1 C (PTP1C) is a tyrosine phosphatase highly expressed in heomatopoietic cells. PTP1C was found to co-precipitate with B lymphocytespecific cell surface glycoprotein CD22, after anti-immunoglobulin stimulation. Study with PTP1C deficient mice showed that the phosphatase may implicate with negative selection in B cell immunity.
Synonyms	PTPN-6, HCP, PTP1C, Protein-tyrosine phosphatase 1C, PTP-1C, SH-PTP1, Protein-tyrosine phosphatase SHP-1
Reference Data
Protein Families	Druggable Genome, Phosphatase, Stem cell - Pluripotency
Protein Pathways	Adherens junction, B cell receptor signaling pathway, Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway

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