Bak (BAK1) Mouse Monoclonal Antibody [Clone ID: AT8B4]

Specifications

Product Data
Clone Name	AT8B4
Applications	ELISA, FC, IF, WB
Recommend Dilution	ELISA. Western blot: 1/250-1/500. Flow Cytometry. Immunocytochemistry/Immunofluorescence. Immunofluorescence: 1/250-1/500.
Reactivity	Human, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant Human BAK1 (29-187aa) purified from E. coli
Specificity	The antibody recognizes Human and Mouse BAK1. Other species not tested.
Formulation	PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein-G Affinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	BCL2 antagonist/killer 1
Database Link	Entrez Gene 12018 MouseEntrez Gene 578 Human UniProt ID Q16611
Background	BAK1 encodes an receptor-like kinase (RLK) with a putative extracellular domain, a single transmembrane domain, an intracellular-juxtamembrane domain, and a kinase domain. BAK1 expression is associated with the progression of Prostate cancer (CaP). BAK1 appears to function in distinct receptor-signaling complexes to integrate multiple microbe-associated molecular pattern (MAMP) perception into downstream-signaling events. BAK1 can serve multiple purposes to simultaneously modulate MAMP-receptor complexes, BR signaling, and cell death for the benefit of bacterial infection, life style, and fitness.
Synonyms	BAK1, BAK, BCL2L7, Bcl2-L-7, CDN1
Reference Data
Protein Families	Druggable Genome, Stem cell - Pluripotency, Transmembrane

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