CD175 Mouse Monoclonal Antibody [Clone ID: TN218]

CAT#: AM10039PU-N

CD175 mouse monoclonal antibody, clone TN218, Supernatant

Size: 500 ul 1 ml



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CNY 5,665.00


货期*
5周

规格
    • 1 ml

Product images

Specifications

Product Data
Clone Name TN218
Applications IF, IHC
Recommend Dilution Immunohistochemistry and Immunocytochemistry (Frozen or Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections and cell smears): 1/50-1/100 using streptavidin~biotin system or polymer system, incubate 30 minutes at room temperature.
Immunofluorescence.
Recommended Positive Control: Human gastrointestinal tumor.
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen Asialo ovine submaxillary mucin (AOSM).
Specificity This antibody stains Tn antigen in epithelial carcinoma, pancreatic, colon, stomach, breast.
Cellular Localization: Cytoplasmic and epithelial membrane.
Formulation PBS, pH 7.4 containing 0.05% Sodium Azide as preservative.
State: Supernatant
State: Liquid concentrated cell culture medium.
Concentration lot specific
Conjugation Unconjugated
Storage Condition Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Background Aberrant glycosylation is a hallmark of cancer cells. The blood group precursors T (Thomsen-Friedenreich) and Tn epitopes are shielded in healthy and benign-diseased tissues but uncovered in approx. 90% of carcinomas. T and Tn glycoproteins are specific, autoimmunogenic pancarcinoma antigens. These antigens may also be found in neoplastic blood cells Fundamental chemical and physical aspects of these glycoproteins of primary carcinomas are discussed first. Tn and T epitopes are cell and tissue adhesion molecules, essential in invasion by and metastasis of carcinoma which includes adherent and proliferative phases. Immunohistochemical studies of the extent of Tn antigen expression in primary breast carcinoma demonstrate it highly significant correlation with clinicopathological tumor stages, and hence its value as a reliable prognosticator.
Synonyms Blood Group Tn Antigen
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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