Collagen V (COL5A1) Mouse Monoclonal Antibody [Clone ID: 18G5]

Specifications

Product Data
Clone Name	18G5
Applications	ELISA, IF, IHC, IP, WB
Recommend Dilution	ELISA. Western Blot: 1/200-1/1000. Immunoprecipitation. Immunohistochemistry on Paraffin Sections: 15 µg/ml. Immunofluorescence.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant N alpha 1 fragment: Human N alpha 1 (V). The epitope is located in the COL2-NC2 region.
Specificity	Reacts with Human pro alpha 1(V) chain.
Formulation	State: Purified State: Lyophilized powder Preservative: None
Reconstitution Method	Restore in distilled water.
Concentration	lot specific
Purification	Affinity Chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Gene Name	collagen type V alpha 1
Database Link	Entrez Gene 1289 Human UniProt ID P20908
Background	Collagens are highly conserved throughout evolution and are characterized by an uninterrupted "Glycine-X-Y" triplet repeat that is a necessary part of the triple helical structure.Type V Collagen is a member of group I Collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V Collagen binds to DNA, heparan sulfate, Thrombospondin, Heparin, and Insulin. Collagen V is composed of several subunits as follows: trimers of two alpha 1(V) and one alpha 2(V) chains in most tissues and trimers of one alpha 1(V), one alpha 2(V), and one alpha 3(V) chains in placenta. Type V Collagen is closely related to type XI Collagen and it is possible that the Collagen chains of types V and XI constitute a single collagen type with tissue specific chain combinations. Mutations in this gene are associated with Ehlers Danlos syndrome, types I and II.
Synonyms	COL5A1
Reference Data

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