TPX2 Mouse Monoclonal Antibody [Clone ID: 19AT738.292]

Specifications

Product Data
Clone Name	19AT738.292
Applications	WB
Recommend Dilution	ELISA: 1/1,000 Western blotting: 1/100-1/500.
Reactivity	Human, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	This monoclonal antibody is generated from mice immunized with four KLH conjugated synthetic peptides selected from human P100.
Specificity	This antibody is specific to P100.
Formulation	PBS containing 0.09% (W/V) Sodium Azide as preservative. State: Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Purification	Protein G Chromatography eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	TPX2, microtubule nucleation factor
Database Link	Entrez Gene 22974 Human UniProt ID Q9ULW0
Background	The nuclear protein p100 is a proliferation-associated protein whose expression is restricted to cell cycle phases S, G2, and M. Exclusively expressed in proliferating cells from the transition G1/S until the end of cytokinesis. During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. The full-length cDNA encodes a 747-amino acid protein with a putative ATP/GTP-binding site motif. RT-PCR analysis demonstrated strong expression of in lung carcinoma cell lines but not in normal lung tissues. Expression was also found in adult placenta, skeletal muscle, thymus, testis, and small intestine and in fetal brain, liver, and kidney. P100 is also correlated to cancer prognosis.
Synonyms	DIL-2, C20orf1, C20orf2, HCA519
Reference Data

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