IKK gamma (IKBKG) Mouse Monoclonal Antibody [Clone ID: 55AT986.5.78]

Specifications

Product Data
Clone Name	55AT986.5.78
Applications	WB
Recommend Dilution	ELISA: 1/1,000. Western blotting: 1/100-1/500.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	This antibody was raised using purified His-tagged recombinant full length human IKK gamma.
Specificity	This antibody is specific to IKK gamma.
Formulation	PBS containing 0.09% (W/V) Sodium Azide as preservative. State: Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Purification	Protein G Chromatography eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
Database Link	Entrez Gene 8517 Human UniProt ID Q9Y6K9
Background	IKK gamma is a regulatory subunit part of the IKK-signalosome complex activation. It is also considered to be a mediator for TAX activation of NF-kappa-B. This protein could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Defects in IKBKG are the cause of anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID). EDA-ID is a X-linked recessive disorder characterized by absence of sweat glands, sparse scalp hair, rare conical teeth and immunological abnormalities resulting in severe infectious diseases. Defects in IKBKG are the cause of familial incontinentia pigmenti type II (IP2), an X-linked dominant disease causing death in male fetuses. In heterozygous female, it is characterized by disturbance of skin pigmentation sometimes associated with a variety of malformations of the eye, nails, teeth, skeleton, heart, and central nervous system.
Synonyms	FIP3, FIP-3, IKKAP1, I-kappa-B kinase subunit gamma, IKK-gamma, IKKG, IkB kinase subunit gamma
Reference Data

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