CD62L (SELL) Mouse Monoclonal Antibody [Clone ID: DREG56]

Specifications

Product Data
Clone Name	DREG56
Applications	FC, FN, IHC, IP, WB
Recommend Dilution	Flow cytometry: 2 μg/ml. Immunoprecipitation. Western blot: non-reducing conditions. Immunohistochemistry (frozen sections). Functional application: Particularly effective in blocking of lymphocyte CD62L-mediated binding to peripheral lymph node HEV.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	PMA-activated human peripheral blood leukocytes
Specificity	This antibody recognizes CD62L / L-selectin, a 65-76 kDa cell surface protein, expressed by neutrophils, monocytes, and subsets of T, B, and NK cells, that interacts with specific carbohydrates exposed on activated endothelial cells.
Formulation	Buffered saline (PBS), approx. pH 7.4; 0.2 μm filter sterilized State: Low Endotoxin State: Liquid Ig fraction
Concentration	lot specific
Purification	Protein-A affinity chromatography (> 95% pure by SDS-PAGE)
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	selectin L
Database Link	Entrez Gene 6402 Human UniProt ID P14151
Background	CD62L (L-selectin) is an adhesion glycoprotein that is constitutively expressed on the cell surface of leukocytes and mediates their homing to inflammatory sites and peripheral lymph nodes by enabling rolling along the venular wall. CD62L is also involved in activation-induced neutrophil aggregation. Activation-dependent CD62L shedding, however, counteracts neutrophil rolling. CD62L has also signaling roles including enhance of chemokine receptor expression. Similarly to CD62P, the major ligand of CD62L is PSGL-1 (P-selectin glycoprotein ligand-1). The level of CD62L expression can be used to help distinguish naive T cells from effector/memory T cells.
Synonyms	SELL, LNHR, LYAM1, Leu-8, TQ1, gp90-MEL, LECAM1, LAM-1
Reference Data

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