CD26 (DPP4) Mouse Monoclonal Antibody [Clone ID: BA5b]

Specifications

Product Data
Clone Name	BA5b
Applications	FC
Recommend Dilution	Flow cytometry: 1.5 μg/ml. Positive control: human peripheral blood leukocytes.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	A human T cell clone
Specificity	The antibody recognizes CD26, a 110 kDa type II membrane glycoprotein, which is a peptidase expressed on mature thymocytes, T cells (especially activated), B cells, NK cells and macrophages.
Formulation	Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 State: Aff - Purified State: Liquid Ig fraction
Concentration	lot specific
Purification	Protein A affinity chromatography (> 95% pure by SDS-PAGE)
Conjugation	Unconjugated
Storage Condition	Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Gene Name	dipeptidyl peptidase 4
Database Link	Entrez Gene 1803 Human UniProt ID P27487
Background	CD26, also known as dipeptidyl peptidase IV (DPP-IV), is a homodimeric cell surface serine peptidase that degradates IFN-gamma-induced cytokines, acts as a T cell costimulatory molecule, and participates in multiple immunopathological roles in leukocyte homing and inflammation. Alterations in its peptidase activity are characteristic of malignant transformation. The enzymatic activity increases dramatically with tumour grade and severity. CD26 is expressed in various blood cell types, but also e.g. in cells that are histogenetically related to activated fibroblasts. Alterations in CD26 density have been reported on circulating monocytes and CD4+ T cells during rheumatoid arthritis and systemic lupus erythematosus.
Synonyms	ADCP2, Dipeptidyl peptidase 4, DPP IV, Dipeptidyl peptidase IV, ADABP, TP103
Reference Data
Protein Families	Druggable Genome, Protease, Secreted Protein, Transmembrane

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