Adenosine Receptor A2a (ADORA2A) (full length) Mouse Monoclonal Antibody [Clone ID: 7F6-G5-A2 / 7F6]

Specifications

Product Data
Clone Name	7F6-G5-A2 / 7F6
Applications	FC, IHC, WB
Recommend Dilution	Flow Cytometry. Immunohistochemistry on Paraffin Sections: 5 µg/ml. IHC-Pfa: 1 µg/ml. Western Blot: 1/1000.
Reactivity	Canine, Guinea Pig, Human, Mouse, Rabbit, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	6His-tagged full-length Human recombinant A2A receptor. Epitope: 3rd Intracellular Domain (SQPLPGER)
Specificity	This antibody recognizes Human Adenosine Receptor A2A at ~43 kDa. Does not recognize Adenosine Receptor A2A in knockout mice.
Formulation	0.01M Tris-Glycine, pH 7.4, 0.15M Sodium Chloride State: Purified State: Liquid purified IgG fraction Preservative: 0.05% Sodium Azide
Concentration	lot specific
Purification	Protein G Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	adenosine A2a receptor
Database Link	Entrez Gene 11540 MouseEntrez Gene 25369 RatEntrez Gene 135 Human UniProt ID P29274
Background	The A2a Adenosine Receptor is a major target of caffeine. This receptor inhibits cell aggregation, induces vasodilation, and downregulates inflammation. This gene encodes a protein which is one of several receptor subtypes for adenosine. The activity of the encoded protein, a G protein coupled receptor family member, is mediated by G proteins which activate adenylyl cyclase. The encoded protein is abundant in basal ganglia, vasculature and platelets and it is a major target of caffeine.
Synonyms	ADORA2A, ADORA2
Reference Data
Protein Families	Druggable Genome, GPCR, Transmembrane
Protein Pathways	Calcium signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction

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