Factor H (CFH) Mouse Monoclonal Antibody [Clone ID: OX-24]

Specifications

Product Data
Clone Name	OX-24
Applications	ELISA, FC, IHC, IP, WB
Recommend Dilution	ELISA. Flow Cytometry. Immunohistochemistry on Paraffin Sections: 20 µg/ml. Immunoprecipitation. Western Blot.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified Human complement factor H protein
Specificity	Clone OX-24 inhibits the binding of factor H to surface bound C3. This antibody recognizes the Human serum complement protein factor H and a 43-49kD truncated form of factor H.
Formulation	PBS containing 0.02% Sodium Azide as preservative. State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein G Chromatography.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	complement factor H
Database Link	Entrez Gene 3075 Human UniProt ID P08603
Background	Factor H (CFH) is a protein with twenty short consensus repeat (SCR) domains. Factor H is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in Factor H have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Synonyms	CFH, HF, HF1, HF2, H factor 1
Reference Data
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Complement and coagulation cascades

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