Bone Sialoprotein (IBSP) (CD-BSP 108-122) Mouse Monoclonal Antibody [Clone ID: 243 8B1]

Specifications

Product Data
Clone Name	243 8B1
Applications	ELISA
Recommend Dilution	ELISA: 1/2000.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant Human CD-BSP
Specificity	Recognizes Carbohydrate-deficient Bone Sialoprotein (CD-BSB/Tumor-BSP).
Formulation	PBS, pH 7.4 State: Purified State: Lyophilized purifed IgG fraction
Reconstitution Method	Restore in aqua bidest to 1 mg/ml
Purification	Protein G Chromatography
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C and reconstituted at -20°C. Avoid repeated freezing and thawing.
Gene Name	integrin binding sialoprotein
Database Link	Entrez Gene 3381 Human UniProt ID P21815
Background	The protein encoded by the Bone Sialoprotein gene is a major structural protein of the bone matrix. It is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts, and it constitutes approximately 12% of the noncollagenous proteins in human bone. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor.
Synonyms	Bone sialoprotein II, BSP II, IBSP, BNSP
Reference Data
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	ECM-receptor interaction, Focal adhesion

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