Hepatitis B Surface Antigen / HBsAg Mouse Monoclonal Antibody [Clone ID: Hs33]

Specifications

Product Data
Clone Name	Hs33
Applications	ELISA
Recommend Dilution	Suitable for use in ELISA. Recommended pair for Sandwich Immunoassay Capture: AM20355PU-N Detection: AM20356PU-N (Sensitivity 50pg/ml).
Reactivity	Hepatitis B Virus
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant HBsAg of ayw subtype
Specificity	This antibody recognizes Hepatitis B virus surface antigen. Reacts with the following HBsAg subtypes: ayw1, ayw2, ayw3, ayw4, ayr, adw2, adw4, adrq+, adrq- and ayw3 (Fer).
Formulation	PBS, pH 7.4 containing 0.09% Sodiumm Azide. State: Purified State: Liquid purified IgG fraction (>/= 95% pure by SDS-PAGE).
Concentration	lot specific
Purification	Protein G Chromatography.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted 2-8°C.
Background	Hepatitis B Virus (HBV) infection induces a disease state characterized by liver damage, inflammation and viral persistence. Infection also increases the risk of hepatocellular carcinoma. HBV belongs to the Hepadnaviridae family of viruses. Its genome consists of partially double stranded circular DNA. The DNA is enclosed in a nucleocapsid, or core antigen (HBcAg), which is surrounded by a spherical envelope (surface antigen or HBsAg). The core antigen shares its sequences with the e antigen (HBeAg) but no cross reactivity between the two proteins has been observed. The HBV genome also encodes a DNA polymerase that also acts as a reverse transcriptase. Hepatitis B infection is normally diagnosed from serological tests that detect HBsAg but as the disease progresses this antigen may no longer be present in the blood and tests for HBcAg are used. If HBsAg can be detected in the blood for longer than six months, chronic hepatitis B is diagnosed. The antigenic determinant of the protein moiety of the HBsAg determines specific characteristics of different serotypes and provides the basis of immunodetection. HBsAg has antigenic heterogeneity, specifically, two pairs of sub specific determinants, d/y and w/r allow the following combinations: adw, ayw, adr, ayr.
Synonyms	HBV surface antigen, Hepatitis B Virus
Reference Data

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