Pea3 (ETV4) (50-109) Mouse Monoclonal Antibody [Clone ID: 1A2G3]

Specifications

Product Data
Clone Name	1A2G3
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA: 1/10000. Immunohistochemistry on Paraffin Sections: 1/200. Western Blot: 1/500 - 1/2000.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant protein encoding amino acids 50-109 of Human ETVA.
Specificity	Recognizes Adenovirus E1a Enhancer Binding Protein (ETV4).
Formulation	State: Ascites State: Ascites fluid containing 0.03% Sodium Azide as preservative.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	ETS variant 4
Database Link	Entrez Gene 2118 Human UniProt ID P43268
Background	ETV4: ets variant gene 4 (E1A enhancer binding protein, E1AF). Several members of the Ets gene family are known to encode sequence specific DNA binding proteins. These include mouse PU.1, mouse and human Ets-1, Drosophila E74, chicken and human Ets-2 and rat GABP-α. Each of these proteins recognizes similar motifs in DNA that share a centrally located 5'-GGAA-3' element. For instance, PEA3 binds the motif 5'-AGGAAG-3' (the PEA-3 motif), but does not bind to the sequence 5'-AGGAAC-3', recognized by PU.1, although PU.1 binds equally well to both sequences. It appears that all of the Ets proteins recognize the same central core sequence but that each protein interacts with unique sequences that flank this core. PEA3 is expressed at readily detectable levels in cells of epithelial and fibroblastic origin but is not expressed in hematopoietic cells. This is in contrast to other members of the Ets gene family, such as Ets-1, Ets-2 and Fli-1, each of which is expressed primarily in cells of hematopoietic origin.
Synonyms	E1AF, E1A-F
Reference Data
Protein Families	Druggable Genome, Transcription Factors

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