TNF alpha (TNF) Mouse Monoclonal Antibody [Clone ID: Mab1]

Specifications

Product Data
Clone Name	Mab1
Applications	ELISA, FN
Recommend Dilution	Western blot. ELISA: Can be used as capture antibody in combination with biotinylated antibody MAb11. Functional application: neutralisation.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human TNF-alpha
Specificity	This antibody recognizes human 17-26 kDa cytokine TNF-alpha (tumor necrosis factor alpha).
Formulation	Azide free phosphate buffered saline (PBS), approx. pH 7.4; 0.2 μm filter sterilized State: Azide Free State: Liquid Ig fraction
Concentration	lot specific
Purification	Protein-A affinity chromatography (> 95% pure by SDS-PAGE)
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	tumor necrosis factor
Database Link	Entrez Gene 7124 Human UniProt ID P01375
Background	TNF-alpha is a cytokine produced by monocytes, macrophages, neutrophils, NK cells, CD4+ T cells and many transformed cells. It can be expressed as a 17 kDa free molecule, or as a 26 kDa membrane protein. TNF-alpha easily forms stable trimers, but also other multimeric complexes. In the immune system, it is an important regulator, which has cytolytic and cytostatic activity against a range of tumor cells, increases fibroblast proliferation and supports neutrophil chemotaxis and phagocytosis.
Synonyms	TNF, TNF-a, TNFA, TNFSF2, Cachectin
Reference Data

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