Factor VIII (F8) Mouse Monoclonal Antibody [Clone ID: F8 2.2.9]

Specifications

Product Data
Clone Name	F8 2.2.9
Applications	IHC
Recommend Dilution	Immunohistochemistry on Paraffin Sections: 10 µg/ml.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	F8 antibody was raised against purified human Factor VIII.
Specificity	This antibody recognizes full-length Human Factor VIII (F8). Does not cross-react with von Willebrand factor.
Formulation	PBS, pH 7.4 State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein G chromatography
Conjugation	Unconjugated
Storage Condition	Upon receipt, store (in aliquots) at -20°C to -80°C. Avoid repeated freezing and thawing.
Gene Name	coagulation factor VIII
Database Link	Entrez Gene 2157 Human UniProt ID P00451
Background	This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.
Synonyms	Procoagulant component, Antihemophilic factor, F8C, AHF
Reference Data
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Complement and coagulation cascades

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